Study Suggests – Cannabis reverses aging processes in the brains

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Memory performance decreases with increasing age. Cannabis can reverse these ageing processes in the brain. This was shown in mice by scientists at the University of Bonn with their colleagues at The Hebrew University of Jerusalem (Israel). Old animals were able to regress to the state of two-month-old mice with a prolonged low-dose treatment with a cannabis active ingredient. This opens up new options, for instance, when it comes to treating dementia. The results are now presented in the journal Nature Medicine.

Like any other organ, our brain ages. As a result, cognitive ability also decreases with increasing age. This can be noticed, for instance, in that it becomes more difficult to learn new things or devote attention to several things at the same time. This process is normal, but can also promote dementia. Researchers have long been looking for ways to slow down or even reverse this process.

 

 

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Scientists at the University of Bonn and The Hebrew University of Jerusalem (Israel) have now achieved this in mice. These animals have a relatively short life expectancy in nature and display pronounced cognitive deficits even at twelve months of age. The researchers administered a small quantity of THC, the active ingredient in the hemp plant (cannabis), to mice aged two, twelve and 18 months over a period of four weeks.

Afterwards, they tested learning capacity and memory performance in the animals — including, for instance, orientation skills and the recognition of other mice. Mice who were only given a placebo displayed natural age-dependent learning and memory losses. In contrast, the cognitive functions of the animals treated with cannabis were just as good as the two-month-old control animals. “The treatment completely reversed the loss of performance in the old animals,” reported Prof. Andreas Zimmer from the Institute of Molecular Psychiatry at the University of Bonn and member of the Cluster of Excellence ImmunoSensation.

Years of meticulous research

This treatment success is the result of years of meticulous research. First of all, the scientists discovered that the brain ages much faster when mice do not possess any functional receptors for THC. These cannabinoid 1 (CB1) receptors are proteins to which the substances dock and thus trigger a signal chain. CB1 is also the reason for the intoxicating effect of THC in cannabis products, such as hashish or marihuana, which accumulate at the receptor. THC imitates the effect of cannabinoids produced naturally in the body, which fulfil important functions in the brain. “With increasing age, the quantity of the cannabinoids naturally formed in the brain reduces,” says Prof. Zimmer. “When the activity of the cannabinoid system declines, we find rapid ageing in the brain.”

To discover precisely what effect the THC treatment has in old mice, the researchers examined the brain tissue and gene activity of the treated mice. The findings were surprising: the molecular signature no longer corresponded to that of old animals, but was instead very similar to that of young animals. The number of links between the nerve cells in the brain also increased again, which is an important prerequisite for learning ability. “It looked as though the THC treatment turned back the molecular clock,” says Zimmer.

Next step: clinical trial on humans

A low dose of the administered THC was chosen so that there was no intoxicating effect in the mice. Cannabis products are already permitted as medications, for instance as pain relief. As a next step, the researchers want to conduct a clinical trial to investigate whether THC also reverses ageing processes in the brain in humans and can increase cognitive ability.

The North Rhine-Westphalia science minister Svenja Schulze appeared thrilled by the study: “The promotion of knowledge-led research is indispensable, as it is the breeding ground for all matters relating to application. Although there is a long path from mice to humans, I feel extremely positive about the prospect that THC could be used to treat dementia, for instance.”

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Materials provided by University of Bonn. Note: Content may be edited for style and length.

Cbd oil for menopause.

CBD for Menopause and PMT

There are cannabinoid receptors in all areas of the female reproductive organs, including both the CB1 and CB2 receptors. Given what we already know about CBD’s influence over these receptors, it’s a logical assumption to believe that CBD could help reduce the signs and symptoms of menopause through interaction in the highly concentrated areas of endocannabinoid receptors.

During menopause, women find it increasingly difficult to sleep. Hot flashes, mood swings and overall discomfort continually disrupt a healthy sleep cycle. Soon, this lack of sleep trickles down into other areas of a woman’s life and eventually increases the severity of all menopausal symptoms.

There is a growing body of research indicating that both CBD, THC and other cannabinoids are beneficial for improved sleep quality. While CBD itself may trigger a mild increase in wakefulness when taken before bed, CBD still facilitates a better and longer nights rest.

Bone Density Loss

Bone density naturally starts to decrease during menopause. In some circumstances, it can lead to future issues with osteoporosis and bone fragility. It’s common for doctors to prescribe ERT simply for the possible improvements to bone density. But, as we’ve discussed, ERT is not always a perfect long-term solution.

Cannabidiol, THCV, CBG, and CBC all are potential candidates for protecting against bone loss. In fact, these specific cannabinoids are known to stimulate bone growth. Cannabidiol, among the other cannabinoids, may represent a perfect alternative to ERT therapy for those women worried about bone density loss.

Mood Stabilizer

Alongside the inevitable hot flashes, the associated menopausal mood swings are an equally taxing part of hormonal changes. As hormones change, it changes the way women process and manage their stress levels. A woman’s body continues to operate as per usual, but with an endocannabinoid deficiency. Its suddenly not as easy to process stress, anger, and daily pressures.

Thankfully, cannabinoids are already making incredible inroads as a powerful replacement to traditional SSRI drugs. It’s a logical next step to bring the mood stabilizing capabilities of CBD, already evidenced for treating depression and anxiety, into the realm of menopausal women.

CBD Oil and Vertigo

cbd oil, The mind

When clients mail me to ask if the CBD oils will help with their conditions I like to do some research for them and put together some information that I find so it may help them in making a decision as to whether they would benefit from CBD oils.

Todays condition is Vertigo

Vertigo feels like you or everything around you is spinning – enough to affect your balance. It’s more than just feeling dizzy.

A vertigo attack can last from a few seconds to hours. If you have severe vertigo it can last for many days or months.

What causes vertigo

Inner ear problems, which affect balance, are the most common causes:

Other things that can cause vertigo:

  • migraine
  • some types of medicine – check the leaflet to see if it’s listed as a side effect

 

Can CBD Oil Help and How??

It is great to know that CBD (cannabinoid) oil can be of benefit to people with vertigo and Meniere’s Disease.  This extract of the cannabis plant can be life-altering for many people.

Because of changing laws, people are rediscovering that cannabis has many health benefits that have not been talked about until recently, though for many years previous to Big Pharmacy’s growth, people were given elixirs containing CBD.




 

What is Meniere’s Disease?

People who suffer from the  intense vertigo (dizziness) and nausea due to an inner ear problem a condition of unknown cause called Ménière’s disease often find significant improvement from cannabis, according to California doctors.

These doctors often approve the use of cannabis by Meniere’s patients who say that it helps ease their symptoms.  “Meniere’s causes dizziness.  Dizziness causes nausea, cannabis relieves nausea”,  Robert Sullivan, MD said,   “I’ve issued many recommendations for Meniere’s, as well as tinnitus (ringing in the ears)   It works well enough to make a significant improvement in patients’ lives.”

Cannabis (CBD oil included) has been shown to stop the spinning.  It also helps with the nausea caused by the dizziness.

 

In 1861, the French physician Prosper Meniere described this condition.  Meniere’s disease is a disorder of the inner ear, which causes episodes of vertigo (dizziness), ringing in the ears (tinnitus), a feeling of fullness or pressure in the ear, and periodic hearing loss.   The area of the ear affected is the entire labyrinth, which includes both the semicircular canals and the cochlea.

A Meniere’s episode generally involves severe vertigo (spinning), imbalance, nausea and vomiting.  The average attack lasts two to four hours.  Following a severe attack, most people find that they are exhausted and must sleep for several hours.


Allan Frankel, M.D., of Greenbridge Medical states the following, “We are all very familiar with both CBD rich and THC rich medicines helping a lot with nausea. In recent months I have seen a number of patients with vertigo from different etiologies. A few have been related to inner ear issues, a few have been associated with local cancers and a few were a part of a systemic neurological disorder.

They seem to share one thing in common; they all seem to respond to CBD in doses of 6 mg per 24 hours.

Treats Nausea

CBD oil can cure vomiting and nausea. The non-psychotropic components of this oil activate certain autoreceptors, which causes antiemetic/anti-nausea effects in the body.

Lowers Inflammation

When it comes to inflammation, some people can only find relief with CBD oil, particularly those with advanced cases of rheumatoid arthritis, multiple sclerosis, migraines, joint disorders, and pervasive muscle pain. [5] In some cases, people have reported nearly miraculous improvement in the inflammatory symptoms of chronic diseases.

Great article on CBD  –   https://www.medicalnewstoday.com/articles/317221.php

I feel comfortable thinking about Vertigo the same way I think of nausea. Both CBD and THC are effective in treating both nausea and vomiting; not all that surprising as they are so frequently related.

So, if you Diagnose Vertigo, think cannabinoids.”

 

 

 

CBD Oil Dosage Calculator

cbd oil

So you get your cbd oils and there is no instruction and you don’t have a clue what your doing?? Firstly you can ask the company to send you out their own dosage advice or the person you bought from should hold information to help you.

I personally find that starting of low is the best way to go and work your way up until you feel the benefits.

There is no “one size fits all” when it comes to determining the “right” CBD dosage. The effective dose for each person is different based on body chemistry, severity of concern, weight, concentration of the product, etc. One or two drops may be effective for one person but another person may need several drops of the same product.

Below is a chart that may help determine the amount of cbd in mg that you may need per day.

 

 

Once you work this out then have input your details into the online cbd oil calculator and this may help you determine the suitable dosage for yourself.  Just bare in mind that we all feel things in different ways so take it slow, increase as desired and relax.  Some people may notice benefits in a few short weeks others takes a few months so stick with it.

Our CBD dosage calculator can help you calculate total drops, milligrams of CBD per drop and number of drops necessary to achieve your desired CBD oil dosage.

Source: CBD Oil Dosage Calculator